Shingles Vaccine Side Effects? You may experience mild side effects like soreness, redness, or swelling at the injection site, but these typically resolve within days. Rarely, more serious reactions, such as severe allergic responses, can occur—seek immediate medical help if you notice difficulty breathing or swelling of the face. Fatigue, headache, or fever might follow, signaling your immune system is responding as intended. To manage discomfort, apply a cool compress or take over-the-counter pain relievers. The vaccine’s benefits—dramatically reducing shingles risk and complications—far outweigh these temporary inconveniences. Stay informed and proactive about your health.